Prof. Dr. Lixin Zhang

Zhang Lixin Ph.D  
Principal Investigator

Prof. Lixin Zhang is Director of State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology. He is also Part-time Professor of Institute of Microbiology, Chinese Academy of Sciences (IMCAS). He is Chief Scientist of a “973 Program” and an Awardee of the National Science Fund for Distinguished Young Scholars, China. Before joining IMCAS in 2006, Prof. Zhang worked in 3 pharmaceutical companies in USA: SynerZ, Cetek and Microbia, Inc. He received his Ph. D degree in Institute of Applied Ecology, CAS and did his postdoc at Emory University, USA. He has published seven books, more than 200 papers (in Nature, etc) and holds 28 Chinese patents and 16 PCT patents. He co-edited a book with Prof. Arnold Demain, member of American Academy of Sciences on natural products in 2005 by Humana Press. He served as the President of the International Chemical Biology Society (ICBS) during 2016-8. He became the president of SLAS Asia Regional Board, Society for Laboratory Automation and Screening in early 2015. He was recognized as an Honorary lifetime member, Sino-American Pharmaceutical Professional Association (SAPA). He has been appointed as an Editor-in-Chief for "Synthetic and Systems Biotechnology", Associate Editor-in-Chief for Applied Microbiology and Biotechnology, and on the editorial board of 6 other peer-reviewed journals. He also served as an Executive Board Member of International Committee on the Biology of Actinomycetes (ISBA) and the GIM (Genetics of Industrial Microorganisms).The long-term goal of the research is to discover and develop synergistic medicines from marine microbial natural products and increase their outputs through synthetic biology approaches.His Avermectin project won Award for "Excellence to improve science and technologies” and the paper was published in PNAS and etc.

Background:



Postdoc Emory University, Atlanta, USA, Pharmacology 1994-1998

Ph.D. Institute of Applied Ecology, CAS Microbiology 1990-1994

B.S. Shandong University, China Microbiology 1986-1990

Research interests:



Discover and develop synergistic medicines from marine microbial natural products.

1. Diversifying marine microbial natural product strains and extracts libraries.

2. Screening for synergistic medicines in a high throughput manner.

3. Increasing the production of drugable secondary metabolites from microbial producers by synthetic biology.

Representative Publications



1. Sci. Adv., 2018, 4(11): 1. 10.1126/sciadv.aau4602; 论文:作者:Ashforth EJ, Fu C, Liu X, Dai H, Song F, Guo H, Zhang L*. 2010. Bioprospecting for antituberculosis leads from microbial metabolites. Nat Prod Rep. 27(11):1709-19.27(11)(2010);起止页码:第1709 页至第1719 页IF=9.38

2. Zhang L*, Kezhi Yan, Yu Zhang, Ren Huang, Jiang Bian, ChuansenZheng, Haixiang Sun, Zhihui Chen, Nuo Sun, Rong An, Fangui Min, Weibo Zhao, Ying Zhuo, Jianlan You, Yongjie Song, Zhenyan Yu, Zhiheng Liu, Keqian Yang, Hong Gao, Huanqin Dai, Xiaoli Zhang, Jian Wang, Chengzhang Fu, Gang Pei, Jintao Liu, S;题目:Highthroughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections;期刊名称:Proc Natl Acad Sci U S A;卷(期)(年):104(11)(2007);起止页码:第4606 页至第4611 页IF=8.88

3. Zhuo Ying, Zhang Wenquan, Chen Difei, Gao Hong, Tao Jun, Liu Mei, Gou Zhongxuan, Zhou Xianlong, Ye Bangce, Zhang Qing, Zhang Siliang, Zhang Lixin*;题目: Reversebiological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis;期刊名称:Proc. Natl. Acad. Sci. U S A;卷(期)(年):107(25)(2010);起止页码:第11250 页至第11254 页IF=9.598

4. Gao Q, Tan GY, Xia X, Zhang LX*. 2017. Learn from microbial intelligence for avermectins overproduction. Curr Opin Biotechnol. 48:251-257. 期刊名称:Current Opinion In Biotechnology;卷(期)(年):

5. Wupeng Yan, Heng Song, Fuhang Song, Yisong Guo, Cheng-Hsuan Wu, Ampon Sae Her, Yi Pu, Shu Wang, Nathchar Naowarojna, Andrew Weitz, Michael P. Hendrich, Catherine E. Costello, Zhang L*, Pinghua Liu*, and Yan Jessie Zhang*;题目:Endoperoxide Formation Catalyzed by FtmOx1,an α-Ketoglutarate-dependent Mononuclear Non-heme Iron Enzyme;期刊名称:Nature;卷(期)(年):527(2015);起止页码:第539 页至第543 页IF=7.714

6. Bai C, Zhang Y, Zhao X, Hu Y, Xiang S, Miao J, Lou C*, Zhang L*;题目:Exploiting a precise design of universal synthetic modular regulatory elements to unlock the microbial natural products in Streptomyces;期刊名称:Proc Natl Acad Sci U S A;卷(期)(年):112 (39)(2015);起止页码:第12181 页至第12186 页IF=9.598

7. Wang Qian, Song Fuhang, Xiao Xue, Huang Pei, Li Li, Aaron Monte, Wael M. Abdel-Mageed, Wang Jian, Guo Hui, He Wenni, Xie Feng, Dai Huanqin, Liu Miaomiao, Chen Caixia, Xu Hao, Liu Mei, Andrew M. Piggott, Liu Xueting*, Robert J. Capon*, Zhang Lixin*;题目:Abyssomicins from the South China Sea deep-sea sediment Verrucosispora sp.: Natural thioether Michael addition adducts as antitubercular prodrugs;期刊名称:Angew. Chem.-Int. Edit;卷(期)(年):52(4)(2013);起止页码:第1231 页至第1234 页

8. Zhang, L., J. Chen and H. Fu.;题目:Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins;期刊名称:Proc Natl Acad Sci USA;卷(期)(年):96 (15)(1999);起止页码:第8511 页至第 8515 页IF=7.714

Book:Lixin Zhang* and Arnold L.Demain;著作名称:Natural Products: Drug Discovery, Therapeutic Medicine;出版社:Humana Press;出版年份:2005;出版地:USA

Public service



Editorial board, Applied Microbiology and Biotechnology

Editorial board, Marine Biotechnology

Editorial board, Journal of Antibiotics (Japan)

Editorial board, Frontiers in Antimicrobials, Resistance and Chemotherapy

Editorial board, Chinese Journal of Biotechnology

Editorial board, Journal of Antibiotics (China)

SELECTED HONORS AND RECOGNITION



2011: Awardee for National Distinguished Young Scholar Program, China.

2011: Outstanding mentorship Awards, Chinese Academy of Sciences

2009: The only Outstanding Paper Award of ISHAM Satellite Symposia Beijing, China

2007: Chinese Academy of Sciences K. C. Wong Awards

2007: The New Century National ‘Bai Qian Wan’ Talent Project

2006: Hundred Talent Project, Chinese Academy of Sciences (Final evaluation: Outstanding, 2011)

2004: Outstanding Mentor Award, Siemens Westinghouse Competition, USA

TRAINEES



Total graduate students trained: 8; total postdoctoral trainees: 5; total undergraduate trainees: 10.


Selected Publications

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