Prof. Dr. Lixin Zhang

Zhang Lixin Ph.D  
Principal Investigator

Prof. Lixin Zhang is a Deputy Director of CAS Key Laboratory of Pathogenic Microbiology & Immunology, Institute of Microbiology, Chinese Academy of Sciences (IMCAS). Before joining IMCAS in 2006, Dr. Zhang worked in 3 pharmaceutical companies in USA: SynerZ, Cetek and Microbia, Inc. He received his Ph. D. degree in Institute of Applied Ecology, CAS and did his postdoc at Emory University, USA. He has published seven books, more than 100 papers and holds eleven PCT patents. He co-edited a book with Prof. Arnold Demain on natural products in 2005 by Humana Press. He served as an Executive Board Member of International Symposium on the Biology of Actinomycetes (ISBA) and The International Chemical Biology Society (ICBS). He was recognized as an Honorary lifetime member, Sino-American Pharmaceutical Professional Association (SAPA). He has been appointed as an associate Editor-in-Chief for “Applied Microbiology and Biotechnology” and on the editorial board of 6 other peer-reviewed journals. The long-term goal of his research is to discover and develop synergistic medicines from marine microbial natural products. His research is focused on: Diversifying marine microbial natural product library; screening for synergistic medicines in a high throughput manner; increasing the production of drugable secondary metabolites from microbial producers by synthetic biology (serve as a chief PI for a 973 program). His Avermectin project won Award for "Excellence to improve science and technologies” and the paper was published in PNAS. He was recognized as an Awardee for National Distinguished Young Scholar Program, China.

Background:



Postdoc Emory University, Atlanta, USA, Pharmacology 1994-1998

Ph.D. Institute of Applied Ecology, CAS Microbiology 1990-1994

B.S. Shandong University, China Microbiology 1986-1990

Research interests:



Discover and develop synergistic medicines from marine microbial natural products.

1. Diversifying marine microbial natural product strains and extracts libraries.

2. Screening for synergistic medicines in a high throughput manner.

3. Increasing the production of drugable secondary metabolites from microbial producers by synthetic biology.

Five Representative Publications



Zhuo, Y., Zhang, W.Q, Chen, D.F., Gao, H., Liu, J.T., Liu, M., Gou, Z.X., Zhou, X.L., Wang, Q., Ye, B.C., Zhang, Q., Zhang, S.L., L.X. Zhang. 2010. Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis. Proc Natl Acad Sci USA 107: 11250-11254.IF=9.38

Ashforth, E.J., Fu, C.Z., Liu, X.Y., Dai, H.Q., Song, F.H., Guo, H. and L.X. Zhang. 2010. Bioprospecting for antituberculosis leads from microbial metabolites. Nat Prod Rep 27:1709-1719.IF=8.88

Zhang, L.X., Yan, K.Z., Zhang, Y., Huang, R., Bian, J., Zheng, C., Sun, H., Chen, Z., Sun, N., An, R., Min, F., Zhao, W.Q., Zhuo, Y., You, J.L., Song, Y., Yu, Z., Liu, Z.H, Yang, K., Gao, H., Dai, H.Q., Zhang, X., Wang, J., Fu, C.Z, Pei, G., Liu, J.T., Zhang, S., Goodfellow, M., Jiang, Y.Y., Kuai, J., Zhou, G., X.P. Chen. 2007. High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections. Proc Natl Acad Sci USA 104:4606-4611.IF=9.598

Demain, A.L., and L.X., Zhang. 2005. Natural Products Based drug discovery. (Ed: Zhang, L and A. Demain.), "Natural Products: Drug Discovery and Therapeutic Medicine", ISBN: 1-58829-383-1, Humana Press, USA.

Zhang, L.X., An, R., Wang, J., Sun, N., Zhang, S., Hu, J.C., J. Kuai. 2003. Exploring novel bioactive compounds from marine microbes. Curr Opin Microbiol 8:276-281.IF=7.714

Public service



Editorial board, Applied Microbiology and Biotechnology

Editorial board, Marine Biotechnology

Editorial board, Journal of Antibiotics (Japan)

Editorial board, Frontiers in Antimicrobials, Resistance and Chemotherapy

Editorial board, Chinese Journal of Biotechnology

Editorial board, Journal of Antibiotics (China)

SELECTED HONORS AND RECOGNITION



2011: Awardee for National Distinguished Young Scholar Program, China.

2011: Outstanding mentorship Awards, Chinese Academy of Sciences

2009: The only Outstanding Paper Award of ISHAM Satellite Symposia Beijing, China

2007: Chinese Academy of Sciences K. C. Wong Awards

2007: The New Century National ‘Bai Qian Wan’ Talent Project

2006: Hundred Talent Project, Chinese Academy of Sciences (Final evaluation: Outstanding, 2011)

2004: Outstanding Mentor Award, Siemens Westinghouse Competition, USA

TRAINEES



Total graduate students trained: 8; total postdoctoral trainees: 5; total undergraduate trainees: 10.


Selected Publications

People