Projects & Grants

Ongoing Projects

National Program on Key Basic Research Project (973 Program) (NO. 2013CB734000)
Study on the compatibility of the synthetic microbial systems
合成微生物体系的适配性研究

Project of National Great New Drug Research and Development (NO. 2011ZX09102-011-11)
Preclinical study of the synergistic antifungal compound beauvericin
互动抗真菌药物白僵菌素的临床前研究

National Science and Technology Key Project on “Major Infectious Diseases such as HIV/AIDS, Viral Hepatitis Prevention and Treatment” (NO. 2013ZX10005004-005)
Synergistic anti-TB substances from TCMs and their medicinal mechanism
基于互动筛选技术揭示治疗耐药结核中药复方的物质基础及其作用机制

National Natural Science Foundation of China (Key Program) (NO.31430002)
Bioprospecting and genome mining of anti-TB bioactive molecules from marine verrucosispora Sp.
从海洋疣孢菌属中勘探和挖掘抗结核分枝杆菌活性的小分子

International Cooperation and Exchange of the National Natural Science Foundation of China (NSFC) (NO. 31320103911)
Targeting host-pathogen interactions for novel Antibiotics
针对病原菌与宿主互作关系筛选获得克服耐药菌的新型抗生素

National Science Fund for Distinguished Young Scholars (No. 31125002)
Study on mechanisms of antifungal drug resistance of natural products from Microbe
微生物活性物质抗耐药真菌的机制研究

China Ocean Mineral Resources R & D Association (NO. DY125-15-T-07)
Screening and Potential Valuation of Marine Microbes for Agriculture Application
深海农用活性微生物的筛选与应用潜力评价

Collaborative project “PharmaSea”
“Increasing Value and Flow in the Marine Biodiscovery Pipeline” (Grant agreement number312184)
欧盟第七框架计划

National Program on Key Basic Research Project (973 Program) (NO. 2012CB725203)
Characterization of artificial strain producing PHA
生物基材料工程菌株的功能检测与分析

National Program on Key Basic Research Project (973 Program) (NO. 2012CB721006)
Global transcriptional regulatory mechanism of Avermectin biosynthesis
阿维菌素生物合成基因相关全局转录调控模块作用机制解析

General Program of the National Natural Science Foundation of China (NSFC) (NO. 31170095)
The analysis and optimalization of the genes related to avemectin high-production
阿维菌素高产相关基因的解析与优化

National Natural Science Foundation of China (NSFC) (NO. 31400090)
Mechanism study of novel antimicrobials stimulating host immunity
新型宿主免疫调节抗菌化合物的作用机制研究

National Natural Science Foundation of China (NSFC) (NO. 81302678)
NanoDESI-LTQ-FT mass spectrum assisted MS/MS networking guided identification of anti-TB microbial natural products
基于NanoDESI-LTQ-FT质谱和小分子化合物网络快速鉴定微生物来源的抗结核活性成分

Cooperation program with enterprises
Construction of Coenzyme Q10 high-production strain
辅酶Q10菌种生产能力提高

Cooperation program with enterprises
Microbialtransformation of bioactive compounds from plant
植物活性物的微生物转化

Finished Projects

International Science & Technology Cooperation Program of China (NO.2007DFB31620)
Marine actinomycetes: diversity and prospecting for natural drugs and clean industrial biocatalysts
海洋放线菌:多样性及在天然药物和清洁工业生物催化剂中的研究

National High-tech R&D Program of China (863 Program); (NO. 2007AA09Z443)
Screening synergistic antifungal compounds from deep sea microorganism by methods of metagenomics
利用宏基因组技术筛选深海微生物中互动抗真菌活性物质

National High-tech R&D Program of China (863 Program); (NO. 2006AA09Z402)
Screening the anticancer drugs using high throughput screening combine with synergistic screening from marine microbiology
利用互动高通量技术筛选海洋微生物抗肿瘤先导化合物

Bill Gates and TB Global Alliance Project
Discovery of anti-TB compounds from new drugs
结核病新药发现计划

Hundred talents Program of the Chinese Academy of Sciences, 2006
High Throughput Screening of Marine Microbes and Secondary Metabolites
海洋微生物及其代谢产物库的高通量筛选研究

Project of National Great New Drug Research and Development (NO. 2009ZX09302-004)
High-Tech Innovation Platform of Microbial Medicine Screening
特殊生境真菌代谢

Main Direction Program of Knowledge Innovation of the Chinese Academy of Sciences; (NO. KSCX2-YW-R-164)
The pathogenesis and rapid diagnosis of TB and new anti-TB drug discovery
结核分枝杆菌致病机制、快速诊断和新型药物研究

National Key Technology Research and Development Program of the Ministry of Science and Technology of China (NO. 2007BAI26B02)
Precise designment of fermentation medium and optimization of fermentation process
发酵培养基精确设计及发酵过程优化

Project of National Great New Drug Research and Development (NO. 2008ZX09401005-005)
Fermentation and extraction technology research of new anticancer and antibacterial compound produced by microbiology
微生物产生的新型抗癌和抗菌抗生素新产品的发酵和提取工艺研究

International Cooperation and Exchange Project of the National Natural Science Foundation of China (NSFC) (NO. 812111049)
Harvard-wide Program on Antibiotic Resistance
微生物来源的抗MRSA和VRE化合物筛选与作用机制研究

International Cooperation and Exchange of the National Natural Science Foundation of China (NSFC) (NO. 30911120483)
High-throughput screening and identification of anti- Viral myocarditis compounds from a unique natural product library
从海洋微生物天然产物中筛选抗心肌炎病毒类化合物

International Cooperation and Exchange of the National Natural Science Foundation of China (NSFC) (NO. 30911120484)
High-throughput screening and identification of anti-TB compounds from a unique natural product library
从海洋微生物天然产物库中高通量筛选抗TB的天然产物

International (Regional) Cooperation and Exchange Program of National Natural Science Foundation of China (NO. 30950110337)
Identification of Natural Product Inhibitors of M. tuberculosis growth
抑制结核分枝杆菌生长的天然产物的鉴定

National Natural Science Foundation of China for young investigator Program (NSFC) (NO. 81102369)
Investigation of anti-TB compounds from marine-derived Verrucosispora
海洋疣孢菌属抗结核杆菌活性成分的研究

International (Regional) Cooperation and Exchange Program of National Natural Science Foundation of China (NO. 31050110430 )
Natural Products from Microbes
微生物天然产物研究

General Program of the National Natural Science Foundation of China (NSFC) (NO. 30700015)
Study mechanism on micorbial metaboliteson target in 14-3-3 for cancer
针对14-3-3靶点的微生物活性产物抗癌机制研究

General Program of the National Natural Science Foundation of China (NSFC) (NO. 30873129)
Mechanism research on reversible efflux-mediated drug resistance of berberine
小辟碱逆转多药耐药泵MDR1机制的研究

General Program of the National Natural Science Foundation of China (NSFC) (NO. 30973665)
Latency mechanism study of phosphate tyrosine phosphatase(PtpA) inhibitors screened from natural products
结核菌酪氨酸磷酸酶(PtpA)小分子抑制剂的筛选及其对潜伏期分子机制研究

National Natural Science Foundation of China for young investigator Program (NSFC) (NO. 30901849)
Screening and Mechanism of anti-MRSA Compounds from Marine Microorganism
特异抑制MRSA活性微生物天然产物的筛选及其机制研究

National Natural Science Foundation of China for young investigator Program (NSFC) (NO. 81102356)
High throughput screening for new anti-tuberculosis antibiotics targeting malate synthase
以苹果酸合酶为靶点筛选抗结核持留菌的新型微生物先导化合物

National Natural Science Foundation of China for young investigator Program (NSFC) (NO. 81102362 )
Preparation of L-DOPA by biotransformational system on the basis of microbial culture library and metagenomic library
利用宏基因组文库和微生物菌种库构建高效转化制备L-DOPA的酪氨酸酶体系

National Natural Science Foundation of China for young investigator Program (NSFC) (NO. 31100075)
Investigation of the optimized global transcriptional HrdB on avermectin biosynthesis
全局转录因子HrdB调控阿维菌素高产机制研究

National Natural Science Foundation of China for young investigator Program (NSFC) (NO. 31000057)
Engineering the transcription regulatory factor in the biosynthetic pathway of avermectin
阿维菌素生物合成途径全局调控因子的精确改造与功能分析

Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDA04074000 )
The experimental scheme research of the adaptation and response mechanisms for life on earth to space environment
地球生命对空间环境的适应与响应机制实验方案研究

Strategic Priority Research Program of the Chinese Academy of Sciences
The origin of space life and search of extraterrestrial life
空间生命起源与地外生命探索


Selected Publications

Projects & Grants