Before Joining IM, CAS

  1. Zhang, L., and A. Demain. (Editors-in-Chief) 2005. " Natural Products: Drug Discovery, Therapeutic Medicine ", ISBN: 1-58829-383-1, Humana Press, USA
  2. Jia, W and L. Zhang*. 2005. Challenges and opportunities in the Chinese Herbal Drug Industry. (Ed: Zhang, L and A. Demain.), " Natural Products: Drug Discovery, and Therapeutic Medicine ", ISBN: 1-58829-383-1, Humana Press, USA.
  3. Sun, N and L. Zhang*. 2005. siRNA in C. elegans. (Ed: Song E.), SiRNA Research: theory, applications and methods . Science publishing, China.
  4. Sun, N and L. Zhang*. 2005. siRNA in Drosophila. (Ed: Song E.), SiRNA Research: theory, applications and methods . Science publishing, China.
  5. Zhang, L*. 2005. Integrated approaches of discovering novel drugs from microbial natural products. (Ed: Zhang, L and A. Demain.), " Natural Products: Drug Discovery and Therapeutic Medicine ", ISBN: 1-58829-383-1, Humana Press, USA. P33-56
  6. Zhang, L*. 2005. The Renaissances of Natural Products for Drug Discovery. (Ed: Zhang, L and A. Demain.), " Natural Products: Drug Discovery and Therapeutic Medicine ", ISBN: 1-58829-383-1, Humana Press, USA.
  7. Jia, W and L. Zhang*. 2005. Challenges and opportunities in the Chinese Herbal Drug Industry. (Ed: Zhang, L and A. Demain.), " Natural Products: Drug Discovery, and Therapeutic Medicine ", ISBN: 1-58829-383-1, Humana Press, USA.
  8. Zhang, L*., An, R.; Wang, J.; Sun, N.; Zhang, S.; Hu, J.; Kuai, J. 2005. Exploring novel bioactive compounds from marine microbes. Current Opinion In Microbiology, 8(3): 276-281 IF=7.654
  9. Zhang, L*., An R, J Wang, N Sun, S Zhang, J Hu, J Kuai. 2005. Isolation of novel bioactive compounds from marine microbes. Current Opinion In Microbiology, 8(3): 276-281
  10. Zhang, L. 2005. Coupling systems biology approach for synergistic drug discovery. Cell Research. 15(10): 92.
  11. Fujii K, Goldman EH, Park HR, L. Zhang, Chen J, Fu H. 2004. Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034. Oncogene 23:5099-6104.
  12. FKnight V., JJ Sanglier, D DiTullio, S Bracilli, P Bonner, J Waters, D Hughes, L Zhang*. 2003. Diversifying microbial natural products for drug discovery. Applied Microbiology and Biotechnology 62: 446–458.
  13. Guo, J. et al. 2003. Tele-microscopic morphology observation of pathogens in shrimp. P205-206. In: Wang, S et al. (ed.), Studies on Terrestrial & Marine and Soil microorganism. ISBN: 7-5381-4123-5, Shenyang publishing, Shenyang, China.
  14. Zhang, L., J. Chen, and H. Fu. 2003. 14-3-3 structures and function. P63-70. In: Wang, S et al. (ed.), Studies on Terrestrial & Marine and Soil microorganism. ISBN: 7-5381-4123-5, Shenyang publishing, Shenyang, China.
  15. Pierceal, W., L. Zhang, and D. Hughes. 2003. Affinity capillary electrophoresis analyses of protein-protein interactions in target-directed drug discovery. ( ed: Haian Fu), " Methods in Molecular Biology, vol 261: Protein-Protein Interactions", Humana Press In., USA, 187-197.
  16. Chen, J., K. Fujii, L. Zhang, T.M.Roberts and H. Fu. 2001. Raf-1 promotes cell survival by antagonizing apoptosis signal regulating kinase 1 in a MEK-ERK independent mechanism. Proc. Natl. Acad. Sci. USA. 98(14): 7783-7788
  17. Masters, S., K. Pederson, L. Zhang, J. Barbieri, and H. Fu. 1999. Interaction of 14-3-3 with a Nonphosphorylated Protein Ligand, Exoenzyme S of Pseudomonas aeruginosa. Biochemistry. 38(16):5216-5221
  18. Zhang, L. J. Chen and H. Fu. 1999. Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins. Proc. Natl. Acad. Sci. USA. 96 (15): 8511-8515.
  19. Wang, B., H. Yang, Y. Liu, T. Jelinek, L. Zhang, H. Fu, and E. Ruoslahti. 1999 Disrupting 14-3-3 interaction with Raf-1 and ADPRTs with a high affinity peptide antagonist. Biochemistry 38: 12499-12504.
  20. Zhang, L., H. Wang, B. Wang, J. Barbieri and H. Fu. 1999 Residues in the conserved amphipathic groove of 14-3-3 required for activation of Exoenzyme S of Pseudomonas aeruginosa. Biochemistry 38: 12159-12164.
  21. Zhang, L., H. Fu. 1998. Interaction of 14-3-3 proteins with ASK1 kinase that activates SAPK/JNK and p38 pathways. Proteins, 540
  22. Wang, H., L. Zhang, R. Liddington, and H. Fu. 1998. Mutations in the hydrophobic surface of an amphi- pathic groove of 14-3-3 disrupt its interaction with Raf-1 kinase. J.Biol.Chem. 273 : 16297-16304.
  23. Megidish, T., J. Cooper, L. Zhang, H. Fu, and S. Hakomori. 1998. A novel sphingosine-dependent protein kinase is associated with and specifically phosphorylates certain isoforms of 14-3-3 protein. J.Biol.Chem.. 273 (34): 21834-21845.
  24. Zhang, L., H. Wang, D. Liu, R. Liddington, and H. Fu. 1997. Raf-1 kinase and Exoenzyme S interact with 14-3-3 through a common site involving lysine-49. J.Biol.Chem. 272 (21): 13717-13724.
  25. Zhang, L. 1995. Conventional and genetic engineering to improve the yield of Rifamycin SV by A. mediteranei. Dissertation, Academia Sinica. Available: Microfilms in the Inst. of Applied Ecology, CAS
  26. Wu, W., C. Zhang, A. Lu, and L. Zhang. 1995. Isolation and properties of Rifamycin SV inactivation factor produced by A. mediteranei. Journal of Applied Ecology. 6 (3): 282-286.
  27. Zhang, L., C. Liu, J. Kuai, and P. Gao. 1994. Construction of a cDNA library of Sporocytophage B29 and Cloning of the CMCase gene. Journal of Applied Ecology. 5 (2): 156-158.
  28. Zhang, L., C. Zhang, A. Lu, and W. Wu. 1993. Rational screen model for high yield Rifamycin SV strains. P625-633. In: X.W. Zhang (ed.), Soil microbiology Research: theory, applications and methods . Shenyang publishing, Shenyang, China.
  29. Zhang, L., J. Wang, X. Guo, and J. Kuai. 1993. Studies on the extraction of PHB [ poly(b-hydroxybutyric acid )]from Sphaerotilus nataus. Journal of Microbiology 13 (1): 30-34.
  30. Wang, S., Z. Li, D. Xue, Q. Lu, and L. Zhang. 1992. The new fermentation technology of mutual adaptation in Vitamin C bilateral gene. Journal of Microbiology 12 (2): 80-82.

Selected Publications

Publications